elevated il-17 and tgf-β serum levels: a positive correlation between t-helper 17 cell-related pro-inflammatory responses with major depressive disorder

نویسندگان

mohammad hasan davami department of immunology and microbiology, school of medicin, jahrom university of medical sciences, jahrom, iran.

rasoul baharlou department of immunology and microbiology, school of medicin, jahrom university of medical sciences, jahrom, iran.

abbas ahmadi vasmehjani department of immunology and microbiology, school of medicin, jahrom university of medical sciences, jahrom, iran.

ahmad ghanizadeh department of psychiatry, school of medicin, shiraz university of medical sciences, shiraz, iran.

چکیده

introduction: depression is a mental disorder that highly associated with immune system. therefore, this study compares the serum concentrations of il-21, il-17, and transforming growth factor β (tgf-β) between patients with major depressive disorder and healthy controls. methods: blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. the subjects were interviewed face to face according to dsm-iv diagnostic criteria. depression score was measured using completed beck depression inventory in both groups. the serum concentrations of il-21, il-17, and tgf-β were assessed using elisa. results: the mean score of beck depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. il-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/ml, respectively (p=0.0002). tgf-β level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs. 174.8±27.20 pg/ml, (p<0.0001). however, the level of il-21 was not statistically different between the two groups 84.30±4.57 vs. 84.12±4.15 pg/ml (p>0.05). conclusion: considering pro-inflammatory cytokines, current results support the associationof inflammatory response and depressive disorder. so, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts.

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Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder

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عنوان ژورنال:
basic and clinical neuroscience

جلد ۷، شماره ۲، صفحات ۱۳۷-۱۴۲

کلمات کلیدی
[ ' m a j o r d e p r e s s i v e d i s o r d e r ' , ' i n t e r l e u k i n ' , 1 7 , ' i n t e r l e u k i n ' , 2 1 , ' t r a n s f o r m i n g g r o w t h f a c t o r ' , ' b e t a ' , ' i n f l a m m a t o r y r e s p o n s e ' ]

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